Biotin and derivatives
Medchemexpress LLC TCO-NHS Ester (axial) | 1610931-22-0 | C13H17NO5 | 25 MG
TCO-NHS Ester axial is a click chemistry reagent that functions as a building block in amine reactions. It contains TCO groups, which are capable of undergoing inverse electron demand Diels-Alder (iEDDA) reactions with molecules that contain Tetrazine groups. This product has a purity of ≥98.0% and is intended for research use only.
- Functions as a building block in amine reactions
- Contains TCO groups capable of inverse electron demand Diels-Alder (iEDDA) reactions with Tetrazine groups
- Purity of ≥98.0%
- Appears as a white to off-white solid
- Intended for research use only
Apexbio Technology LLC HyperFluor™ 555 NHS Ester 1mg
HyperFluor 555 NHS Ester is a fluorescent labeling reagent targeting primary amines (R NH ) on biomolecules It is designed to facilitate covalent conjugation with proteins amine-modified oligonucleotides and other primary amine-containing biomolecules via its NHS ester moiety HyperFluor 555 NHS Ester exerts its activity through amine-specific covalent labeling Based on these properties HyperFluor 555 NHS Ester holds research potential in fluorescence microscopy and flow cytometry for labeling and detection of proteins and oligonucleotides
Medchemexpress LLC Biotin LC hydrazide (biotinamidocaproyl hydrazide) | 109276-34-8 | MFCD00077659 | 99.8% | 371.50 g/mol | C16H29N5O3S | 100 MG
Biotin LC hydrazide is a long-chain biotinylation reagent that reacts with periodate-oxidized glycoproteins and glycans to introduce biotin labels for detection, affinity capture, and conjugation workflows. It is carbohydrate-reactive and reported to be more sensitive than simple biotin hydrazide, improving labeling efficiency in biochemical assays.
- Long-chain hydrazide reagent for labeling oxidized carbohydrates.
- Reacts with periodate-oxidized glycoproteins and glycans.
- Higher sensitivity than biotin hydrazide for improved detection.
- Soluble in DMSO for solution preparation.
- Suitable for biotinylation of proteins, glycans, and nucleic acids.
Medchemexpress LLC MeCY5-NHS ester triethylamine | 00-00-0 | 96.2% | 777.94 g/mol | C36H40N3KO10S2 | 5 MG
MeCY5-NHS ester (potassium) is an amine-reactive Cy5-family fluorescent dye supplied as the NHS-ester potassium salt for labeling proteins, peptides, and nucleic acids in fluorescence assays and imaging.
- Reactive N-hydroxysuccinimide (NHS) ester for covalent labeling of primary amines.
- Cy5-family near-infrared fluorescence, approx. 649/670 nm excitation/emission.
- Potassium salt form with improved water solubility for aqueous labeling.
- Supplied with analytical documentation, including SDS, COA, 1H NMR, and LC-MS.
- Available in lab-scale quantities suitable for conjugation experiments.
Apexbio Technology LLC Cy3 Bis NHS ester 25mg
Cy3 Bis NHS ester is a water-soluble fluorescent labeling reagent containing two amine-reactive NHS ester groups on a single dye molecule This compound specifically reacts with primary amines such as lysine residues on proteins or amine-modified nucleic acids enabling covalent fluorescent conjugation Upon formation of stable amide bonds with target molecules Cy3 fluorescence can be detected with standard fluorescence instruments exhibiting excitation at approximately 550 nm and emission near 570 nm Typical applications encompass labeling proteins peptides antibodies nucleic acids and other amine-containing biomolecules for fluorescence microscopy flow cytometry and biochemical assays as well as single-molecule fluorescence resonance energy transfer (FRET) studies
Apexbio Technology LLC Biotin-11-CTP 1ml (100 mM)
Biotin-11-CTP is a substrate for SP6 T3 and T7 RNA polymerases It can substitute CTP in RNA labeling reactions with biotin during in vitro transcription Biotin-labeled RNA probes can be detected using streptavidin conjugates and are widely utilized in many molecular biology applications such as in situ hybridization and gene expression microarrays
Medchemexpress LLC DBCO-NHS ester 3 100mg | 1393350-27-0 | 416.43 | C24H20N2O5 | 100 MG
DBCO-NHS ester 3 is an amine-reactive dibenzocyclooctyne (DBCO)-based N-hydroxysuccinimide (NHS) ester used as a clickable linker for constructing antibody-drug conjugates and for labeling amine-containing biomolecules via strain-promoted alkyne-azide cycloaddition. Supplied as a 100 MG solid for research use.
- Amine-reactive NHS ester enables covalent coupling to primary amines.
- DBCO moiety supports copper-free click chemistry (SPAAC) with azides.
- Suitable for antibody-drug conjugate linker synthesis and protein labeling.
- Provided in small research-scale solid quantities for laboratory workflows.
- Molecular formula C24H20N2O5; molecular weight 416.43 g/mol.
Medchemexpress LLC Biotin-PEG3-acid 1g | 252881-76-8 | 447.55 | C19H33N3O7S | 1 G
Biotin-PEG3-acid is a biotin-labeled, PEG-based PROTAC linker used to introduce a biotin tag with a short PEG3 spacer in PROTAC synthesis and bioconjugation workflows. The material is supplied as a 1 g purified solid (typical purity 98.0%) with molecular weight 447.55 g/mol and chemical formula C19H33N3O7S, and is accompanied by a batch-specific certificate of analysis.
- Provides a biotin handle separated by a PEG3 spacer to reduce steric hindrance
- Designed for incorporation into PROTACs and other bioconjugates
- Improves aqueous solubility compared with direct biotinylation
- Typically supplied with batch certificate showing ~98.0% purity
- Solid form with known molecular weight and formula for formulation planning
Medchemexpress LLC NSP-SA-NHS | 199293-83-9 | 99.65% | 50 MG
NSP-SA-NHS is an acridinium ester that can be used for chemiluminescent immunoassay. A rapid and sensitive chemiluminescent immunoassay of Bisphenol A (BPA) with NSP-SA-NHS-labeled has been developed.
- Application: Chemiluminescent immunoassay.
- Specific use: Developed for a rapid and sensitive chemiluminescent immunoassay of Bisphenol A (BPA).
Medchemexpress LLC Biotin-PEG-biotin | 194920-55-3 | 99.3% | C26H44N6O6S2 | 10MG
Biotin-PEG-Biotin is a biotin-terminated polyethylene glycol (PEG) linker designed for use in PROTAC assembly and biotin-based affinity workflows. It provides dual biotin handles separated by a flexible PEG spacer, enabling conjugation, capture, and detection applications.
- Biotinylated at both ends for affinity capture and pull-down workflows.
- Peg spacer provides flexibility and improved solubility in polar organic solvents.
- High purity for research applications - 99.3%.
- Soluble in DMSO (~175 mg/mL); ultrasonic treatment may aid dissolution.
- Store protected from light and under inert atmosphere; follow cold storage guidance.
Medchemexpress LLC NHS-MMAF | 1404073-19-3 | 97.2% | 943.18 | 50 MG
NHS-MMAF is a modified MMAF extracted from patent WO2012143499, specifically intermediate 219. MMAF is a potent tubulin polymerization inhibitor and is used as an antitumor agent.
- Modified MMAF.
- Functions as a potent tubulin polymerization inhibitor.
- Used as an antitumor agent.
- Intended for research use only.
Medchemexpress LLC Biotin-EDA | 111790-37-5 | 97.5% | 1 G
Biotin-EDA is an alkyl chain-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs are designed to exploit the intracellular ubiquitin-proteasome system for the selective degradation of target proteins. This compound has a molecular weight of 286.39 and appears as a solid, white to off-white substance.
- Alkyl chain-based PROTAC linker
- Used in the synthesis of PROTACs
- PROTACs contain two different ligands connected by a linker
- PROTACs exploit the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Solid, white to off-white appearance
- For research use only
Apexbio Technology LLC Concanavalin A (Con A)-Biotin 5x5mg(5 mg/mL)
Concanavalin A (Con A) is a lectin protein derived from Canavalia ensiformis (jack bean) with a molecular weight of approximately 104 kDa Each subunit can bind one Ca2 and one Mn2 ion and contains a carbohydrate-binding site Upon binding these metal ions Con A specifically binds to glycoproteins glycolipids and carbohydrates containing -D-glucose and -D-mannose residues Biotin is a small-molecule water-soluble vitamin that exhibits very strong affinity to avidin Concanavalin A-Biotin is a labeled protein conjugate composed of Concanavalin A linked to biotin widely used in biological research especially for detecting and quantifying biomolecules containing specific carbohydrate structures through immunohistochemistry (IHC) immunocytochemistry (ICC) and enzyme-linked immunosorbent assay (ELISA)
Medchemexpress LLC DBCO-biotin | 1418217-95-4 | MFCD22380751 | 98.5% | 502.63 g·mol⁻1 | C28H30N4O3S | 10MG
DBCO-Biotin is a bifunctional click-chemistry reagent that links a dibenzocyclooctyne (DBCO) reactive moiety to a biotin affinity tag, enabling copper-free strain-promoted alkyne-azide cycloaddition (SPAAC) for bioconjugation and probe development. Supplied as a high-purity solid for laboratory research, it is commonly used in bioconjugation, affinity enrichment, and linker synthesis applications.
- Enables copper-free click chemistry via DBCO-mediated SPAAC.
- Provides a biotin tag for affinity capture and detection.
- High purity suitable for sensitive bioconjugation workflows.
- Available in small mg-scale quantities for research use.
- Stable when stored under recommended conditions; consult safety data for handling.
Medchemexpress LLC Biotin-ATRA-conjugate | 2226143-93-5 | 98.4% | C36H55N3O4S | 10MG
ATRA-biotin (biotin-ATRA-conjugate) is a biotin-labeled derivative of all-trans retinoic acid used as a tracer and affinity reagent to track ATRA distribution and interactions in biological samples. It supports biotin-streptavidin workflows and is supplied at high purity for research use only.
- Biotin tag enables streptavidin-based detection.
- Suitable for localization studies in cells and tissues.
- Compatible with pull-down and affinity capture assays.
- High purity for reproducible experimental results.
- Available in multiple laboratory-friendly pack sizes.